Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT2B receptor antagonists in vitro – a potential pathway affecting proliferation
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چکیده
منابع مشابه
5‐HT 2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo
Pulmonary fibrosis is characterized by excessive accumulation of connective tissue, along with activated extracellular matrix (ECM)-producing cells, myofibroblasts. The pathological mechanisms are not well known, however serotonin (5-HT) and 5-HT class 2 (5-HT2) receptors have been associated with fibrosis. The aim of the present study was to investigate the role of 5-HT2B receptors in fibrosis...
متن کامل5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure
OBJECTIVE The serotonin (5-HT) pathway was shown to play a role in pulmonary hypertension (PH), but its functions in right ventricular failure (RVF) remain poorly understood. The aim of the current study was to investigate the effects of Terguride (5-HT2A and 2B receptor antagonist) or SB204741 (5-HT2B receptor antagonist) on right heart function and structure upon pulmonary artery banding (PAB...
متن کاملIncreased expression of p21 in kidney proximal tubules mediates fibrosis
Megyesi J, Tarcsafalvi A, Li S, Hodeify R, Hti Lar Seng NS, Portilla D, Price PM. Increased expression of p21 in kidney proximal tubules mediates fibrosis. Am J Physiol Renal Physiol 308: F122–F130, 2015. First published November 26, 2014; doi:10.1152/ajprenal.00489.2014.—Tissue fibrosis is a major cause of death in developed countries. It commonly occurs after either acute or chronic injury an...
متن کاملModulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice.
Serotonin (5-hydroxytryptamine; 5-HT) is known to increase proliferation and collagen synthesis by fibroblasts. Two receptor subtypes, 5-HT2A and 5-HT2B, have been shown to play the most important roles in the lung. In the present study, the role of serotonin in lung fibrosis was investigated using the bleomycin mouse model. Serotonin concentrations in lung homogenates increased significantly o...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-20430-0